OCTAGAM® 10% [Immune Globulin Intravenous (Human)] liquid

dosing and
administration

Infusion rate chart

Infusion rate calculator

Dosing and rate of administration for adult patients with cITP^1*

60% of patients (54 of 90) achieved the maximum infusion rate allowed at 12 mg/kg/min in the cITP clinical study¹

Monitor the patient carefully throughout the infusion¹
- Certain adverse reactions may be related to the rate of infusion
- Slowing or stopping the infusion usually allows the symptoms to disappear promptly
- Once the symptoms subside, the infusion may then be resumed at a lower rate

For patients at risk of renal dysfunction or thromboembolic events, administer OCTAGAM 10% at the minimum infusion rate practicable¹

Example infusion ramp-up schedule for an adult patient with cITP

Infusion rates ranged from 1 mg/kg/min up to a maximum of 12 mg/kg/min¹
OCTAGAM 10% should be started at 1 mg/kg/min and continued at the infusion rates stated here, if tolerated¹
The example shown here illustrates an infusion ramp-up schedule for a 80-kg patient with cITP using rates of 4, 8, and 12 mg/kg/min

The OCTAGAM 10% infusion rate chart below will help you calculate the appropriate infusion rate for an adult patient with cITP¹

For patients with cITP: 2 g/kg divided in equal doses given over 2 consecutive days
For patients judged to be at risk for developing renal dysfunction or thromboembolic events, administer OCTAGAM 10% at the minimum infusion rate practicable, not to exceed 0.03 mL/kg/min (3.3 mg/kg/min)—equal to 2.0 mL/kg/hr (200 mg/kg/hr)

Download the OCTAGAM 10% cITP Infusion Rate Chart

Step 1: Choose indication¹

With this calculator, you can determine:

infusion ramp-up rate to program into an IV infusion pump
estimated time to complete the infusion

Choose an indication:

Step 2: Enter patient's body weight and OCTAGAM 10% dose for this infusion

Patient with DM one field from each section below needs to be completed before proceeding to the next step.

Enter patient’s body weight

and

Enter patient’s OCTAGAM 10% dose for this infusion*

Calculated answer: Recommended ramp-up infusion rates¹

Patient with DM based on patient’s body weight of {{weight}} kg and a dose of {{dose}} g of OCTAGAM 10%, see below for recommended ramp-up infusion rates

First 30 minutes

0.01 mL/kg/min
(1 mg/kg/min)

mL/hr

Next 15-30 minutes

(if previous is tolerated)

0.02 mL/kg/min
(2 mg/kg/min)

mL/hr

Maximum Infusion Rate

(if previous is tolerated)

0.04 mL/kg/min
(4 mg/kg/min)

≤{{doseGrams.maxInfusion}}

mL/hr

Estimated time to infuse {{dose}} g ({{doseMl}} mL) is between {{infusionTime}}

(if the rates above are tolerated by the patient)

Step 2: Enter patient's body weight and OCTAGAM 10% dose for this infusion

Patient with cITP one field from each section below needs to be completed before proceeding to the next step.

Enter patient’s body weight

and

Enter patient’s OCTAGAM 10% dose for this infusion*

Calculated answer: Recommended ramp-up infusion rates¹

Patient with cITP based on patient’s body weight of {{weight}} kg and a dose of {{dose}} g of OCTAGAM 10%, see below for recommended ramp-up infusion rates

First 30 minutes

0.01 mL/kg/min
(1 mg/kg/min)

mL/hr

Next 30 minutes

(if previous is tolerated)

0.02 mL/kg/min
(2 mg/kg/min)

mL/hr

Next 30 minutes

(if previous is tolerated)

0.04 mL/kg/min
(4 mg/kg/min)

mL/hr

Next 30 minutes

(if previous is tolerated)

0.08 mL/kg/min
(8 mg/kg/min)

mL/hr

Maximum Infusion Rate

(if previous is tolerated)

0.12 mL/kg/min
(12 mg/kg/min)

≤{{doseGrams.maxInfusion}}

mL/hr

Estimated time to infuse {{dose}} g ({{doseMl}} mL) is between {{infusionTime}}

(if the rates above are tolerated by the patient)

* Daily infusion dose, not the total infusion dose, which may be split over 2-5 days.