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HomeAboutDMDMTrial design and efficacySafety and tolerabilityDosing and infusion ratesPatient profilescITPcITPTrial design and efficacySafety and tolerabilityDosing and infusion ratesMaterialsSupportSupportOCTAGAM 10% Co-Pay ProgramPfizer IGuide™FAQsRequest a RepresentativeIg CompanionCoverage
Prescribing Information, including BOXED WARNINGIndicationsPatient SiteOCTAGAM 5%
About

On this page: Storage and handling  Vial sizes and NDC numbers

Biochemical composition and manufacturing

Storage and handling

OCTAGAM 10% [Immune Globulin Intravenous (Human)] liquid storage and handling1

  • OCTAGAM 10% is not supplied with an infusion set. If a filtered infusion set is used (not mandatory), choose a filter size of 0.2 – 200 microns
  • Components used in the packaging of OCTAGAM 10% are not made with natural rubber latex
  • May be stored in the refrigerator for 36 months at 36 °F to 46 °F (2 °C to 8 °C) from the date of manufacture
  • Within this shelf life, the product may be stored up to 9 months at room temperature ≤77 °F (25 °C). After storage at ≤77 °F (25 °C), the product must be used or discarded
  • Do not freeze. Do not use frozen OCTAGAM 10%
  • Do not use after expiration date
  • Dispose of any unused product or waste material in accordance with local requirements
Vial sizes and NDC numbers Overdosage

With intravenous administration, overdose of OCTAGAM 10% may lead to fluid overload and hyperviscosity. Patients at risk of complications of fluid overload and hyperviscosity include elderly patients and those with cardiac or renal impairment.1

Biochemical composition and manufacturing

OCTAGAM 10% [Immune Globulin Intravenous (Human)] liquid is a solution for intravenous infusion that does not contain sucrose or other preservatives1

FractionationCold ethanol, ultrafiltration, chromatography
Total protein (mg/mL)~100 (≥96% lgG) 
IgA (μg/mL)106 (average)
Maltose (mg/mL)90
Sodium (mmol/L)≤30
pH4.5-5.0
Osmolality (mOsmol/kg)310-380
 Next page: DM > LoadingReference:

Octagam 10%. Prescribing Information. Octapharma USA Inc.; 2023.

OCTAGAM 10% for DMFor adults with DM, OCTAGAM 10% is the first and only FDA-approved intravenous immunoglobulin (IVIg) to be indicated for the treatment of this chronic inflammatory disease that affects the muscle and skin.1 Learn more about DMOCTAGAM 10% for cITPFor adults with cITP, OCTAGAM 10% is used to rapidly increase the platelet count in the blood to help control or prevent bleeding.1Learn more about cITPLoading

DM dosing and infusion rates

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INDICATIONS AND USAGE OCTAGAM® 10% [Immune Globulin Intravenous (Human)] liquid is indicated for the treatment of chronic immune thrombocytopenic purpura (cITP) to rapidly raise platelet counts to control or prevent bleeding in adults and for dermatomyositis (DM) in adults.
 Please click here for full Prescribing Information, including BOXED WARNING.
IMPORTANT SAFETY INFORMATION WARNING: THROMBOSIS, RENAL DYSFUNCTION, AND ACUTE RENAL FAILURE
  • Thrombosis may occur with immune globulin intravenous (IgIV) products, including OCTAGAM 10% liquid. Risk factors may include: advanced age, prolonged immobilization, hypercoagulable conditions, history of venous or arterial thrombosis, use of estrogens, indwelling central vascular catheters, hyperviscosity, and cardiovascular risk factors. Thrombosis may occur in the absence of known risk factors.
  • Renal dysfunction, acute renal failure, osmotic nephrosis, and death may occur in predisposed patients who receive IgIV products, including OCTAGAM 10% liquid. Patients predisposed to renal dysfunction include those with a degree of pre-existing renal insufficiency, diabetes mellitus, age greater than 65, volume depletion, sepsis, paraproteinemia, or patients receiving known nephrotoxic drugs. Renal dysfunction and acute renal failure occur more commonly in patients receiving IgIV products containing sucrose. OCTAGAM 10% liquid does not contain sucrose.
  • For patients at risk of thrombosis, renal dysfunction, or acute renal failure, administer OCTAGAM 10% liquid at the minimum dose and infusion rate practicable. Ensure adequate hydration in patients before administration. Monitor for signs and symptoms of thrombosis and assess blood viscosity in patients at risk for hyperviscosity.
Dosing and Administration Patients with dermatomyositis are at increased risk for thromboembolic events; monitor carefully and do not exceed an infusion rate of 0.04 mL/kg/min. ContraindicationsOCTAGAM 10% liquid is contraindicated in patients who have a history of severe systemic hypersensitivity reactions, such as anaphylaxis, to human immunoglobulin and in IgA-deficient patients with antibodies against IgA and history of hypersensitivity.Warnings and PrecautionsOCTAGAM 10% liquid may cause hypersensitivity in patients with a corn allergy. OCTAGAM 10% liquid contains maltose, which is derived from corn. Monitor renal function, including blood urea nitrogen and serum creatinine, and urine output in patients at risk of developing acute renal failure. Falsely elevated blood glucose readings may occur during and after the infusion of OCTAGAM 10% liquid with testing by some glucometers and test strip systems. Hyperproteinemia, increased serum osmolarity, and hyponatremia may occur in patients receiving OCTAGAM 10% liquid. Hemolysis that is either intravascular or due to enhanced red blood cell sequestration can develop subsequent to treatment with OCTAGAM 10% liquid. Risk factors for hemolysis include high doses and non–O-blood group. Closely monitor patients for hemolysis and hemolytic anemia. Aseptic meningitis syndrome may occur in patients receiving OCTAGAM 10% liquid, especially with high doses or rapid infusion. Monitor patients for pulmonary adverse reactions (transfusion-related acute lung injury [TRALI]). OCTAGAM 10% liquid is made from human plasma and may contain infectious agents, eg, viruses and, theoretically, the Creutzfeldt-Jakob disease agent. Adverse Reactions cITP - The most common adverse reactions reported in >5% of study subjects were headache, fever, and increased heart rate. DM - The most common adverse reactions reported in >5% of study subjects were headache, fever, nausea, vomiting, increased blood pressure, chills, musculoskeletal pain, increased heart rate, dyspnea, and infusion site reactions.You are encouraged to report adverse events related to Pfizer products by calling 1-800-438-1985 (US only). If you prefer, you may contact the US Food and Drug Administration (FDA) directly.
Visit www.fda.gov/MedWatch or call 1-800-FDA-1088.OCTAGAM® is a registered trademark of Octapharma AG.Please click here for full Prescribing Information, including BOXED WARNING.INDICATIONS AND USAGEOCTAGAM® 10% [Immune Globulin Intravenous (Human)] liquid is indicated for the treatment of chronic immune thrombocytopenic purpura (cITP) to rapidly raise platelet counts to control or prevent bleeding in adults and for dermatomyositis (DM) in adults.